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With stakes so high, its easy to see why novelists find outbreaks of disease so compelling.

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Here are 20 great fictional takes, ranging from the historical to the futuristic.

Plagues are like imponderable dangers that surprise people, Gabriel Garcia Marquez told the New YorkTimesin 1988.

They seem to have a quality of destiny.

A Journal of the Plague Year by Daniel Defoe (1722)

In this world, cancer has been cured but life spans have been reduced as an unexpected consequence.

Its a novel in which concepts of sickness, health, and mortality itself are turned on their heads.

Its also reflective of Rymans approach to fiction.

Pale Horse, Pale Rider by Katherine Anne Porter (1939)

In a 2006 interview, he said, Stories make us sick.

Neuroses and psychoses are just stories we tell ourselves and believe.

Griffiths award-winning novel uses a futuristic epidemic to address questions of gender and society.

The Plague by Albert Camus (1947)

The novels narrator runs a beauty salon, which becomes a hospice for those afflicted.

In the Nobel Prizewinning authorsBlindness, a growing number of people within a city find themselves unable to see.

The governments response is heavy-handed and authoritarian.

The Andromeda Strain by Michael Crichton (1969)

Adrians fiction blends his own career in medicine alongside the mythological and fantastical.

Mandels story is an ultimately hopeful one, focusing on the ways art endures.

Ma describes a fictional epidemic that taps into anxieties about both pandemics and nostalgia.

The Stand by Stephen King (1978)

Its a resonant metaphor for the way the past can burden us.

The plague here takes a more surreal tone.

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Love in the Time of Cholera by Gabriel Garcia Marquez (1985)

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Journal of the Plague Years by Norman Spinrad (1988)

The Child Garden by Geoff Ryman (1989)

Ammonite by Nicola Griffith (1992)

Beauty Salon by Mario Bellatin (1994)

Blindness by José Saramago (1995)

The Years of Rice and Salt by Kim Stanley Robinson (2002)

Oryx and Crake by Margaret Atwood (2003)

The Children’s Hospital by Chris Adrian (2006)

The Transmigration of Bodies by Yuri Herrera (2013)

Station Eleven by Emily St. John Mandel (2014)

Find Me by Laura van den Berg (2015)

Severance by Ling Ma (2018)

The Book of M by Peng Shepherd (2018)

The Old Drift by Namwali Serpell (2019)